Publications
2017
Characterization of Plasma Membrane Ceramides by Super-Resolution Microscopy. Burgert A, Schlegel J, Bécam J, Doose S, Bieberich E, Schubert-Unkmeir A, Sauer M. Angew Chem Int Ed Engl. 2017 Apr 5. doi: 10.1002/anie.201700570. [Epub ahead of print]
Li C, Wu Y, Riehle A, Kamler M, Gulbins E, Grassmé H. Staphylococcus aureus survives in cystic fibrosis macrophages forming a reservoir for chronic pneumonia. Infect & Imm, in press, 2017
Li C, Wu Y, Riehle A, Orian-Rousseau V, Gulbins E, Grassmé H. Regulation of Staphylococcus aureus infection of macrophages by CD44 and acid sphingomyelinase. Plos Pathogens, in revision, 2017
2016
Hollmann, C., Werner, S., Avota, E., Reuter, D., E., Japtok, L., Kleuser, B., Gulbins, E., Becker, K.A., Schneider-Schaulies, J., and Beyersdorf, N. (2016). Inhibition of acid sphingomyelinase allows for selective targeting of CD4+ conventional versus Foxp3+ regulatory T cells. J Immunol. In press
Simonis A, Schubert-Unkmeir A (2016) Interactions of meninigcoccal virulence factors with endothelial cells at the human blood-cerebrospinal fluid barrier and their role in pathogenicity. FEBS Letters 6. 8. 2016
Tabazavareh ST, Seitz A, Jernigan P, Sehl C, Keitsch S, Lang S, Kahl BC, Edwards M, Grassmé H, Gulbins E, Becker KA (2016). Lack of sphingosine causes suceptiblity to pulmonary Staphylococcus Aureus infections in Cystic fibrosis. Cell Physiol Biochem 38:2094-2102
Mateus-Gil P, Letschert S, Doose S, Sauer M (2016) Super-Resolution Imaging of Plasma Membrane Proteins with Click Chemistry. Frontiers Cell Dev Biology. 9. 9. 2016
Collenburg L, Walter T, Burgert A, Müller N, Seibel J, Japtok L, Kleuser B, Sauer M, Schneider-Schaulies S. (2016) A Functionalized Sphingolipid Analogue for Studying Redistribution during Activation in Living T Cells. J Immunol. Apr 1. pii: 1502447
Doran KS, Fulde M, Gratz N, Kim BJ, Nau R, Prasadarao N, Schubert-Unkmeir A, Tuomanen EI, Valentin-Weigand P (2016). Host–pathogen interactions in bacterial meningitis. Review Acta Neuropathologica. Acta Neuropathol. Feb;131(2):185-209. doi: 10.1007/s00401-015-1531-z. Epub 2016 Jan 7
Li C, Peng H, Japtok L, Seitz A, Riehle A, Wilker W, Soddemann M, Kleuser B, Edwards M, Lammas D, Zhang Y, Gulbins E, Grassmé H. (2016) Inhibition of neutral sphingomyelinase protects mice against systemic tuberculosis. Front Biosci (Elite Ed). Jan 1;8:311-25
2015
Henry BD*, Neill DR*, Becker KA*, Gore S, Bricio-Moreno L, Ziobro R, Edwards MJ, Mühlemann K, Steinmann J, Kleuser B, Japtok L, Luginbühl M, Wolfmeier, Scherag A, Gulbins E*, Kadioglu A*, Draeger A*, Babiychuk EB*. Biomimetic, toxin-sequestrating therapy for the treatment of severe invasive bacterial infections. Nat Biotechnol 2015;33:81-8. *Shared first authorship and senior authorship
Peng H, Li C, Kadow S, Henry BD, Steinmann J, Becker KA, Riehle A, Beckmann N, Wilker B, Li PL, Pritts T, Edwards MJ, Zhang Y, Gulbins E, Grassmé H. Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis. J Mol Med (Berl) 2015;93:675-89
Burgert A, Letschert S, Doose S, Sauer M. Artifacts in single‐molecule localization microscopy. Histochem Cell Biol (2015) 144:123–131
2014
Neuber C, Schumacher F, Gulbins E, Kleuser B. Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry. Anal Chem 2014;86:9065-73
Pewzner-Jung Y, Tavakoli Tabazavareh S, Grassmé H, Becker KA, Japtok L, Steinmann J, Joseph T, Lang S, Tuemmler B, Schuchman EH, Lentsch AB, Kleuser B, Edwards MJ, Futerman AH, Gulbins E. Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa. EMBO Mol Med 2014;6:1205-1
Simonis A, Hebling S, Gulbins E, Schneider-Schaulies S, Schubert-Unkmeir A (2014). Differential activation of acid sphingomyelinase and ceramide release crucially detemines invasiveness of Neisseria meningitidis into brain endothelial cell. PLos Path 10(6):e1004160. doi: 10.1371/journal.ppat.1004160. eCollection 2014 Jun.
Faulstich M, Hagen F, Avota E, Kozjak-Pavlovic V, Winkler AC, Xian Y, Schneider-Schaulies S, Rudel T (2014). Neutral sphingomyelinase 2 is a key factor for invasion for disseminated Neisseria gonorrhoeae. Cell Microbiol 2014 Sep 16. doi: 10.1111/cmi.12361. [Epub ahead of print]
Mueller N, Avota E, Collenberg L, Gulbins H, Schneider-Schaulies S (2014). The role of the neutral sphingomyelinase in physiological and measles virus (MV) mediated T cell suppression. PLoS Pathog. 2014 Dec 18;10(12):e1004574. doi: 10.1371/journal.ppat.1004574. eCollection 2014 Dec. PMID:25521388
Reviews/Book chapters
Schneider-Schaulies J, Schneider-Schaulies S. (2012): Viral Infections and sphingolipids. In ‚Sphingolipids in Disease’. Gulbins E, Petrache I eds. pp. 321-340
Avota E, Koethe S, Schneider-Schaulies S (2013). Membrane dynamics and interactions in measles virus dendritic cell infections. Cell. Microbiol. 15(2):161-9
Schneider-Schaulies S, Mueller N, Gulbins E (2014). Membrane Microdomains Enriched in CeramidesFrom Generation to Function. In " Cell Membrane Nanodomains: From Biochemistry to Nanoscopy" (p.134-172) Cambi & Lidke Eds., (2014) CRC Press, Taylor & Francis group ISBN 9781482209891
Avota E, Schneider-Schaulies S (2014) The role of sphingomyelin breakdown in measles virus immunomodulation. Cell. Physiol. Biochem. 34(1):20-6. doi: 10.1159/000362981. Epub 2014 Jun 16
Schneider-Schaulies J, Schneider-Schaulies S (2014). Sphingolipids in viral infection. Biol Chem. 2014 Dec 19. pii: /j/bchm.just-accepted/hsz-2014-0273/hsz-2014-0273.xml. doi: 10.1515/hsz-2014-0273. [Epub ahead of print]
Schubert-Unkmeir, A. and Doran, K.S. (2015): Mechanisms of bacterial interaction with cells of the blood-cerebrospinal fluid barrier. In ‘Vascular Responses to pathogens’. Gavins F and Stokes K eds. Academic Press Press INC, 2015, ISBN 9780128010785
Beyersdorf N, Kerkau T, Hünig T. (2015) CD28 co-stimulation in T-cell homeostasis: A recent perspective. ImmunoTargets and Therapy, 4:111-122
Beyersdorf N, Müller N. (2015) Sphingomyelin breakdown in T cells: Role in activation, effector functions and immunoregulation. Biol Chem, 396(6-7):749-58
nteractions of meningococcal virulence factors with endothelial cells at the human blood-cerebrospinal fluid barrier and their role in pathogenicity. Simonis A, Schubert-Unkmeir A. FEBS Lett. 2016 Nov;590(21):3854-3867. doi: 10.1002/1873-3468.12344. Epub 2016 Aug 23. Review
Molecular mechanisms involved in the interaction of Neisseria meningitidis with cells of the human blood-cerebrospinal fluid barrier. Schubert-Unkmeir A. Pathog Dis. 2017 Mar 1;75(2). doi: 10.1093/femspd/ftx023
Yuqing Wu, Erich Gulbins, and Heike Grassme´. Crosstalk Between Sphingomyelinases and Reactive Oxygen Species in Mycobacterial Infection Forum ANTIOXIDANTS & REDOX SIGNALING Review Article, in press, 2017
